WASHINGTON — The death of Justice Ruth Bader Ginsburg has touched off a partisan brawl in the Senate to confirm President Trump’s nominee to replace her, a vote that Senator Mitch McConnell of Kentucky, the majority leader, has vowed to hold.
With Democrats all but certain to unite in opposition to Mr. Trump’s nominee — or at least the effort to consider one so close to the presidential election — Mr. McConnell can afford few defections on his side. Republicans hold a 53-to-47 majority in the Senate, meaning they can lose only three votes, with Vice President Mike Pence breaking a 50-50 tie, and still confirm Mr. Trump’s nominee.
Here are four Republicans being closely watched as possible defectors.
Susan Collins of Maine
Ms. Collins, the lone New England Republican remaining in Congress and one of her party’s most politically endangered members, has been a pivotal swing vote in filling vacancies on the Supreme Court, and all eyes are on her in the battle to come.
She is one of two Republican senators who support abortion rights, and has said she would not vote to confirm a nominee who would strike down the landmark 1973 Roe v. Wade case establishing a constitutional right to abortion.
Ms. Collins, who is trying to defend her reputation as a moderate Republican in the toughest race of her political career, recently said she would not be comfortable moving to fill a Supreme Court vacancy in October, just weeks before a general election. Opposing a drive by Mr. Trump to swiftly install a successor to Justice Ginsburg could be a powerful way for her to repair her reputation with moderate voters who turned against her after her vote in 2018 to confirm Brett M. Kavanaugh to the Supreme Court.
But it could also further energize Democratic activists bent on ousting her. Sara Gideon, her Democratic opponent, has already received millions of dollars raised based on Ms. Collins’s support for Justice Kavanaugh, and after Justice Ginsburg’s death, progressive groups were gearing up to pour more money into targeting voters there.
Lisa Murkowski of Alaska
Senator Lisa Murkowski of Alaska was the lone Republican to oppose the confirmation of Justice Kavanaugh in 2018. Like Ms. Collins, she is one of the few remaining Republicans on Capitol Hill who supports abortion rights and has shown a willingness to break with her party in the past.
She made no mention of how she believed the vacancy should be handled in a statement issued late Saturday. But hours before the announcement of Justice Ginsburg’s death, Ms. Murkowski told an Alaska radio station that she would not vote to confirm a Supreme Court nominee before Election Day.
“We are 50 some days away from an election,” she said. Ms. Murkowski is not up for re-election until 2022, so she will not face the immediate electoral judgment of voters as other senators, including Ms. Collins, will.
Mitt Romney of Utah
Senator Mitt Romney, Republican of Utah, had not yet been elected to Congress when the fight to confirm Justice Kavanaugh became a partisan brawl in the Senate. But he, like Ms. Murkowski and Ms. Collins, has shown a willingness to break with the administration and the Republican Party.
Most notably, Mr. Romney became the first senator in American history to vote to remove a president of his own party from office during an impeachment trial — and the only Republican to vote to remove Mr. Trump.
Like other Republicans being watched closely for their position on Mr. Trump’s nominee and the timing of any vote, he made no mention of his position in a statement and instead focused on paying tribute to Justice Ginsburg. And on Friday night, as speculation raged that he had already decided he would not vote on a successor until after Inauguration Day in 2021, a spokeswoman called the reports “grossly false.”
Charles E. Grassley of Iowa
Senator Charles E. Grassley of Iowa, who led the Judiciary Committee in 2016, has said that he would not conduct Supreme Court confirmation hearings in a presidential election year, particularly given the Republican blockade of Merrick B. Garland, Mr. Obama’s pick to replace Justice Antonin Scalia.
But Mr. Grassley no longer oversees the committee. He gave no hint of his intentions in a statement after news of Justice Ginsburg’s death, praising her “sharp legal mind, tenacity and resilience.”